Antibacterial Wound Healing Application of Bio-Inspired Green Silver Nanoparticles: A Review

Authors

  • Nik Ahmad Nizam Nik Malek Centre for Sustainable Nanomaterials (CSNano), Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Mustaffa Shamsuddin Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Juan Matmin Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Khairunadwa Jemon Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Azman Abd Samad Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Muhammad Hariz Asraf Hassan Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Hendra Susanto Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia

DOI:

https://doi.org/10.11113/jomalisc.v2.43

Keywords:

Silver nanoparticles, biosynthesis, antibacterial, wound healing

Abstract

There is a high demand for silver nanoparticles (AgNPs) as a highly effective antimicrobial agent due to its unique properties. However, conventional synthesis methods utilizing toxic chemical reducing agents impose limitations on its applications. Besides, the infected wound by bacteria could increase treatment cost burdening the low-income communities. To address this challenge, a greener approach employing bioresources such as plant extracts as reducing agents has been explored, with the potential to facilitate the utilization of AgNPs in human wound healing applications. This paper reviews development of biosynthesized AgNPs as antimicrobial wound healing agent. The biosynthesized AgNPs using bioresources such as plant extract and microorganisms are effective antimicrobial agent against various types of bacteria related to the wound such as Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and Pseudomonas aeruginosa. At the same time, these biosynthesized AgNPs could accelerate the wound healing process as proven by the in vitro cell study and in vivo animal testing, as compared to the control samples. Hence, the biosynthesized AgNPs could be applied as antimicrobial wound healing agent. 

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Published

2023-11-25

How to Cite

Malek, N. A. N. N., Shamsuddin, M., Matmin, J., Jemon, K., Samad, A. A., Hassan, M. H. A., & Susanto, H. (2023). Antibacterial Wound Healing Application of Bio-Inspired Green Silver Nanoparticles: A Review. Journal of Materials in Life Sciences (JOMALISC), 2(2), 147–153. https://doi.org/10.11113/jomalisc.v2.43

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